Effect of Antioxidants on the Incidence of 7, 12-dimethylbenzanthracene-induced Mammary Tumor in Rats
Yonsei Medical Journal
; : 39-45, 1984.
Article
de En
| WPRIM
| ID: wpr-86206
Bibliothèque responsable:
WPRO
ABSTRACT
The inhibitory effect of selenium, vitamin E, and BHA on DMBA-induced mammary tumorigenesis in rats was investigated. Dietary vitamin E (200 IU/Kg diet) alone could not reduce the tumor incidence at 25 weeks after DMBA administration (10mg DMBA/rat) when selenium was deficient. Selenium supplementation (2ppm in drinking water) to rats fed a practical diet (0.17 ppm Se) reduced the tumor incidence to 14.3% from 75% at 27 weeks after DMBA administration. Dietary supplementation of BHA (0.75%) also reduced the incidence of DMBA-induced mammary tumor to 42.9% at 27 weeks after DMBA-treatment. Rats fed a diet deficient in both selenium and vitamin E contained significantly lower glutathione peroxidase activity and higher malondialdehyde in muscle. However, supplementation of selenium or BHA to the rats fed a practical diet did not alter the malondialdehyde content and glutathione peroxidase activities in muscle, skin and mammary gland. Dietary selenium increased the tissue selenium level. DMBA-induced mammary tumorigenesis was reduced by antioxidants tested but the anticarcinogenic effect of selenium or BHA seems to be independent of glutathione peroxi-dase activity.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Sélénium
/
Vitamine E
/
Hydroxyanisole butylé
/
7,12-Diméthyl-benzo[a]anthracène
/
Animaux
/
Tumeurs expérimentales de la mamelle
/
Antioxydants
Type d'étude:
Incidence_studies
Limites du sujet:
Animals
langue:
En
Texte intégral:
Yonsei Medical Journal
Année:
1984
Type:
Article