CT-guided percutaneous splanchnic nerves block in treatment of advanced pancreatic cancer pain / 中国介入影像与治疗学

ABSTRACT

Objective To explore the effect and safety of CT-guided percutaneous splanchnic nerves block in treatment of advanced pancreatic cancer pain. Methods Thirty patients with advanced pancreatic cancer pain were treated with CT-guided percutaneous splanchnic nerves block. The complications, such as pneumothorax, intractable hypotension, diarrhea, during operation and hospitalization were evaluated using CTCAE v3.0 grading system, and the clinical efficacy was evaluated 1 week after operation. Visual analogue pain scale (VAS) and daily dosage of morphine were assessed before operation and 1 week, 1 month and 3 months after operation, respectively. Results Percutaneous splanchnic nerves block were successfully completed in all 30 patients without pneumothorax, intractable hypotension or arrhythmia during operation and hospitalization. or Ⅱ diarrhea occurred in 6 cases and then cured after symptomatic treatment. There were 5 cases of clinical cure, 21 cases of obvious effect, 4 cases of effective effect 1 week after operation. Postoperative pain relief more than 50% was observed in 26 patients (26/30, 86.67%). VAS and daily dosage of morphine were significantly reduced at 1 week, 1 month and 3 months after treatment compared with those pre-operation (all P<0.05). And VAS at 3 months after treatment was higher than that at 1 week after treatment. Conclusion CT-guided percutaneous splanchnic nerves block has definite efficacy and high safety in treatment of advanced pancreatic cancer pain.