Research progress of biological functions of the major proteins encoded by human cytomegalovirus / 国际儿科学杂志

ABSTRACT

Human cytomegalovirus (HCMV) infection is one of the major causes of birth defects and developmental abnormalities worldwide.It can cause multi-system and multi-organ disease with great harm.HCMV genome can encode multiple functional proteins.In the process of virus infection,the virus itself and host immune regulatory genes are used to help them replicate.The interaction between the encoding proteins and host cytokines determines the final fate of the virus.Understanding the biological functions and potential mechanisms of proteins encoded by these viral genes will help to discover new antiviral drugs,which is of great significance to reduce the pathogenic hazards.In this paper,the mechanism of viral DNA replication and infection process will be further elucidated in terms of the biological functions of the major proteins encoded by HCMV.