Effects of vitamin D levels on lung development in premature infants / 国际儿科学杂志

ABSTRACT

Lung development in premature infants includes alveolar cell differentiation,pulmonary vascular development,alveolar maturation.Vitamin D plays an important role in lung development in premature infants.Studies suggest that premature infants are often deficient or insufficiency in vitamin D.Low vitamin D levels,vitamin D binding protein polymorphisms,and vitamin D receptor gene polymorphisms increase the incidence of bronchopulmonary dysplasia and neonatal respiratory distress syndrome.Vitamin D regulates lung development in premature infants by promoting pulmonary vascular development,reducing inflammatory damage to alveolar epithelial cells,and promoting alveolar maturation,thereby reducing the risk of bronchopulmonary dysplasia,neonatal respiratory distress syndrome,and persistent pulmonary hypertension of newborn.This article reviews the relationship between vitamin D and lung development in premature infants.