Adverse reactions of anti-tuberculosis drugs in children and treatment strategies / 中华实用儿科临床杂志

ABSTRACT

Currently, pediatric tuberculosis is still a serious infectious disease endangering pediatric health, and anti-tuberculosis (TB) therapy is the major treatment for this disease.The course of anti-TB treatment in children is generally long and requires multi-drug combination, which significantly increases the risk of adverse drug reactions(ADRs). Therefore, it is important for pediatricians to have an intimate knowledge of ADRs and countermeasures.The common ADRs in children include anti-TB drug-induced liver injury, skin adverse reactions, gastrointestinal reactions, drug fever, and post-bulbous neuritis.For children with mild and tolerable ADRs, symptomatic treatment should be performed and anti-TB treatment continued.If the adverse reaction is serious or cannot be tolerated, the drug should be stopped in time.If ADRs are complex, serious or rare, multidisciplinary discussion should be conducted to make the best clinical decision.