Effects of different adding time of human milk fortifier on the incidence of complication and catch-up growth of low birth weight premature infants / 中国实用护理杂志

ABSTRACT

Objective:To investigate the effects of different adding time of human milk fortifier on the incidence of complication and catch-up growth of low birth weight premature infants.Methods:A total of 150 low birth weight premature infants were assigned to early fortification group, middle fortification group and delayed fortification group, each 50 cases. In early fortification group, adding human milk firtifier in the enteral intake of 70-85 ml/kg·d, 70-85 ml/kg·d and 86-100 ml/kg·d in the middle fortification group and delayed fortification group, respectively. The incidence of complication and growth development during hospitalization were compared between three groups. Meanwhile, the catch-up growth of low birth weight premature infants were follow-up in three groups.Results:The weight growth rate in the early fortification group was (15.45±2.54) g kg -1·d -1, and middle fortification group was (15.13±2.21) g kg -1·d -1, and the delayed fortification group was (13.50±2.02) g kg -1·d -1, the difference was statistically significant ( F value was 10.676, P<0.01). The incidence of feeding intolerance in the early fortification group was 20.0% (10/50), he middle fortification group was 6.0% (3/50), and delayed fortification group was 4.0% (2/50), the difference was statistically significant ( χ2 value was 8.444, P<0.05). However, there was no significant difference in the incidence of complication and growth development during hospitalization between the three groups ( P>0.05). Repeated measures ANOVA showed that, the differences of body weight, body length and head circumference were statistically significant for the time main effect and group main effect ( F values were 6.291-965.062, P<0.01). In addition, the differences of body length were statistically significant for the group by time interaction ( F value was 5.752, P<0.01). The body weight in the corrected postnatal age 2 months in the early fortification group, middle fortification group and delayed fortification group were (3 017.83±347.40), (2 897.27±315.35), (2 761.22±319.23)g, and the body weight in the corrected postnatal age 3 months were (3 947.67±461.99), (3 844.85±434.68), (3 647.78±418.62)g; the body length in the corrected postnatal age 3 months of the early fortification group, middle fortification group, and the delayed fortification group were (57.87±3.97), (57.19±2.98), (54.27±2.94) cm) and head circumference were (38.13±3.75), (37.13±4.28), (35.42±2.82)cm, the difference was statistically significant ( F values were 6.987, 5.479, 15.035, 6.473, P<0.01). Conclusion:Human milk firtifier with enteral intake of 70-85 ml/kg·d contributes to catch-up growth in low birth weight premature infants, as well as not to the increases in the incidence of feeding intolerance.