Clinical analysis of early-onset group B Streptococcus infection induced purulent meningitis in newborns / 中国小儿急救医学

ABSTRACT

Objective:To explore the value of magnetic resonance imaging(MRI) in clinical diagnosis and prognosis by comparing the clinical features of early-onset group B Streptococcus(GBS)-induced purulent meningitis and the performance of head MRI.Methods:A retrospective analysis was performed on the clinical characteristics and MRI features of 16 neonates with early-onset GBS induced purulent meningitis admitted to Shengjing Hospital of China Medical University from January 2013 to December 2017.Results:Among the 16 neonates with early-onset GBS induced purulent meningitis, there were three cases showing specific neurological symptoms, including varying degrees of convulsions and/or changes in muscle tone.There were two cases showing the general infection manifestations such as lethargy, refusal of milk, low response, and only two cases had fever.Eleven cases of neonates with purulent meningitis had a head MRI examination.There were three cases of brain edema of different degrees, and one of which had ventricular ependymitis; Seven cases had white matter damage, and two cases of which complicated with ventricular hemorrhage.And one case had cerebral infarction.A total of 11 cases were improved or cured clinically, four cases gave up treatment due to serious complications, and one case died in hospital.Conclusion:The incidence of early-onset GBS-induced purulent meningitis is high and the prognosis is poor.The neurological pathological changes of the brain can be found through MRI examination, which provides an objective basis for the diagnosis, treatment and prognosis.