Value of lung ultrasound in diagnosis of transient tachypnea of newborn: a Meta-analysis / 中国小儿急救医学

ABSTRACT

Objective:To evaluate the value of lung ultrasound in diagnosis of transient tachypnea in newborns.Methods:Chinese and English literature search regarding lung ultrasound for the diagnosis of transient tachypnea of the newborn were retrieved in the PubMed Database, Embase Database, Springer, Cochrane library, Wanfang Database and CNKI from inception to August 2018.The Quality Assessment of Diagnostic Accuracy Studies(QUADAS-2) tool was used to assess the quality of studies.The pooled sensitivity, specificity, positive likelihood ratio(PLR), negative likelihood ratio(NLR), and diagnostic odds radio(DOR) were calculated by Meta-Disc 1.4 software, and SROC curve was drawed.Results:A total of eight articles (five in English and three in Chinese) involving 1 582 patients were included.Meta-analysis showed heterogeneity among studies, and random effect model was used.The pooled sensitivity was 0.70 (95% CI was 0.66~0.74), the pooled specificity was 0.96 (95% CI was 0.94~0.97), PLR was 18.71 (95% CI 8.41~41.63), NLR was 0.12 (95% CI was 0.05~0.29), DOR was 279.96 (95% CI was 48.86~1 604.22), area under SROC(AUC) was 0.99, and Cochran-Q was 0.95, respectively. Conclusion:Pulmonary ultrasound has a preferable value for diagnosis of transient tachypnea in newborns.