Clinical observation on the therapeutic effect of Integration of Traditional Chinese and Western Medicine in the treatment of irritable bowel syndrome of diarrhea type of liver depression and spleen deficiency and its influence on inflammatory factors and intestinal mucosal barrier function / 中国基层医药

ABSTRACT

Objective:To explore the therapeutic effect of Integration of Traditional Chinese and Western Medicine in the treatment of irritable bowel syndrome of diarrhea type of liver depression and spleen deficiency, and its influence on inflammatory factors and intestinal mucosal barrier function.Methods:From May 2017 to May 2019, 86 patients with diarrhea-predominant irritable bowel syndrome admitted to the Traditional Chinese Medicine Hospital of Wenling were randomly divided into observation group (43 cases) and control group (43 cases) according to random number table method.The patients in the control group were given trimetastatin tablets, while the patients in the observation group were given traditional Chinese medicine decoction on the basis of the control group.The two groups were treated for 6 weeks.The therapeutic effects, main symptom scores, inflammatory factors, intestinal mucosal barrier function and adverse reactions were compared between the two groups before and after treatment.Results:The total effective rate of the observation group was 93.02%(40/43), which was higher than 67.44%(29/43) of the control group(χ 2=8.871, P<0.05). The main symptom scores of the observation group were (0.52±0.16)points, (0.46±0.12)points, (0.58±0.15)points, (0.39±0.09)points and (0.41±0.10)points, repectively, which were lower than those of the control group[(1.28±0.25)points, (1.16±0.26)points, (1.34±0.27)points, (0.95±0.14)points and (0.93±0.17)points]( t=16.790, 16.030, 16.135, 22.064, 17.289, all P<0.05). The serum levels of IL-6[(8.27±1.38)μg/L] and IL-8[(2.63±0.43)μg/L] in the observation group were lower than those in the control group[(14.39±2.37)μg/L and (4.37±0.56)μg/L]( t=14.633, 16.160, all P<0.05). The levels of plasma endotoxin[(2.68±0.46)U/mL] and D-lactate[(4.87±0.79)μg/L] in the observation group were lower than those in the control group[(3.97±0.63)U/mL and (7.39±0.95)μg/L]( t=10.844, 13.374, all P<0.05). No serious adverse reactions occurred in both two groups. Conclusion:The combination of traditional Chinese and western medicine has good clinical effect in treating diarrhea-predominant irritable bowel syndrome, which can alleviate inflammation and improve intestinal mucosal barrier function, with fewer adverse reactions.