Clinical study on the treatment of functional dyspepsia of liver-stomach disharmony with integrated traditional Chinese and western medicine / 中国基层医药

ABSTRACT

Objective:To explore the clinical effect of integrated traditional Chinese and western medicine in the treatment of functional dyspepsia of liver-stomach disharmony.Methods:From June 2018 to June 2019, 92 patients with functional dyspepsia admitted to Wenling Hospital of Traditional Chinese Medicine were divided into observation group(46 cases) and control group(46 cases) according to random number table method.The control group was treated with trimebutine maleate orally, while the observation group was treated with self-made traditional Chinese medicine decoction on the basis of the control group.Both two groups were treated for 4 weeks.The therapeutic effect, the changes of TCM symptom score, gastric motility index and adverse reactions were compared between the two groups before and after treatment.Results:The total effective rate of the observation group(93.48%) was higher than that of the control group(69.57%)(χ 2=8.731, P<0.05). After treatment, the scores of upper abdominal pain, abdominal distension and early saturated belch acid in the two groups were lower compared with those before treatment(all P<0.05). After treatment, the scores of upper abdominal pain, abdominal distension and early saturated belch acid in the observation group were lower than those in the control group( t=11.068, 22.320, 15.073, 14.369, all P<0.05). After treatment, the levels of serum MLT and LEP in the two groups were higher than those before treatment(all P<0.05), while the level of CRH were lower than those before treatment(all P<0.05). After treatment, the levels of serum MLT and LEP in the observation group were higher than those in the control group, while the level of CRH in the observation group was lower than that in the control group, the differences between the two groups were statistically significant( t=12.022, 15.884, 16.536, all P<0.05). The incidence of adverse reactions in the observation group(4.35%) was lower than that in the control group(23.91%)(χ 2=7.256, P<0.05). Conclusion:The combination of traditional Chinese and western medicine has good effect on functional dyspepsia of liver-stomach disharmony, it can improve gastric motility, and has few adverse reactions, which is worthy of clinical reference.