The relationships between levels of serum microRNA-26b and microRNA-1 and prognosis in elderly patients with stroke depression / 中国医师杂志

ABSTRACT

Objective:To investigate the expressions of microRNA-26b (miR-26b) and microRNA-1 (miR-1) in serum of elderly patients with stroke depression and their relationships with prognosis.Methods:148 elderly stroke patients treated in Hubei Provincial Hospital of Traditional Chinese Medicine from March 2017 to February 2018 were divided into simple stroke group [60 cases, Hamilton Depression Scale (HAMD) score <7 points] and stroke depression group (88 cases, HAMD score ≥7 points). Real-time fluorescence quantitative polymerase chain reaction (qRT-PCR) was used to detect the levels of microRNA-26b and microRNA-1 in the serum of all subjects; the relationships between the expressions of microRNA-26b and microRNA-1 and clinical parameters were analyzed, the relationship between the expressions of microRNA-26b and microRNA-1 and the prognosis of patients were analyzed; Logistic regression was used to analyze the prognostic factors of depression in stroke patients.Results:The expression of microRNA-26b in serum of patients in stroke depression group was significantly lower than that of patients in simple stroke group, and the expression of miR-1 was significantly higher than that of patients in simple stroke group ( P<0.05). The HAMD scores of patients with low expression of microRNA-26b and the high expression of miR-1 were significantly higher than those of patients with high expression of microRNA-26b and the low expression of miR-1 ( P<0.05). Pearson analysis showed that there was a significant negative correlation between microRNA-26b and HAMD score ( r=-0.364, P<0.01), and a significant positive correlation between miR-1 and HAMD score ( r=0.392, P<0.01). In the stroke depression patients with different prognosis, the HAMD score and the expression of miR-1 in the cured group were significantly lower than those in the non-cured group, and the expression of microRNA-26b was significantly higher than that in the non-cured group ( P<0.05). Logistic regression analysis showed that HAMD and miR-1 were the risk factors of poor prognosis in patients with stroke depression, and miR-26b was the protective factor of poor prognosis in patients with stroke depression. Conclusions:The levels of serum miR-1 and mir-26b were increased and decreased in elderly patients with stroke depression. Both of them were related to the prognosis of patients and were the influencing factors of adverse prognosis in patients with stroke depression.