Progress in and deliberation on molecular pathological mechanism of spinal cord injury / 中华创伤杂志

ABSTRACT

Spinal cord injury is still an unsolved medical problem for which the pathological process of spinal cord injury is complex and its molecular pathological mechanism has not been fully revealed. More and more opinions show that spinal cord injury has a unique molecular pathological mechanism at different severities and different stages. Even in the same type of injury, the individual genetic background or personal chronic diseases may affect the severity and prognosis of the injury. The whole-genome sequencing technology can analyze the dynamic development process of all pathological mechanisms of spinal cord injury from acute phase, subacute phase to chronic phase through sequencing analysis of the expression profile of damaged spinal cord tissue, which provides an important theoretical basis for precision intervention of specific pathological mechanisms of spinal cord injury in the future. Herein, the author analyzes the mechanism of spinal cord injury through gene expression profiling, gene expression regulation and post-translational modification, explores the potential and promising therapeutic targets, and thinks over the key scientific issues that need to be solved in the molecular pathological research of spinal cord injury.