Efficacy of cognitive rehabilitation in patients with cognitive dysfunction caused by radiation-induced encephalopathy / 中华放射医学与防护杂志

ABSTRACT

Objective:To evaluate the efficacy and safety of cognitive rehabilitation in the treatment of cognitive dysfunction caused by radiation-induced encephalopathy.Methods:A total of 63 patients with radiation-induced cognitive impairment were divided into treatment group (cognitive rehabilitation combined with conventional therapy) and control group (conventional treatment alone) for 12 weeks. The cognitive function was assessed according to Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) before and after 12 weeks treatment.Results:After 12 weeks treatment, the patients in treatment group demonstrated significant improvement in cognitive function. In treatment group, the scores of patients after cognitive rehabilitation in MoCA and MMSE were obviously higher than the control group( t=5.20, 3.18, P<0.01). The scores in the visual space, naming, attention, abstract thinking, delayed memories and orientating also had improved, with statistically significant difference( t=-3.51, -3.09, -3.18, -2.57, -3.52, -3.39, P<0.05). Conclusions:Cognitive rehabilitation combined with conventional treatment was signally effective in the therapy of cognitive dysfunction caused by radiation-induced encephalopathy.