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Retrospective clinical analysis of 133 cases of stage Ⅳ esophageal cancer / 中华放射肿瘤学杂志
Chinese Journal of Radiation Oncology ; (6): 102-105, 2020.
Article Dans Chinois | WPRIM | ID: wpr-868557
ABSTRACT
Objective To investigate the clinical significance of radiotherapy for stage Ⅳ esophageal cancer.Methods Clinical data of 133 stage Ⅳ esophageal cancer patients admitted to our hospital from 2012 to 2018 were retrospectively analyzed.All patients were assigned into the radiochemotherapy (n=89)and chemotherapy groups (n=44).The survival analysis was performed by Kaplan-Meier method.The multivariate prognostic analysis was conducted by Cox's regression model.Results The 1-,2-and 3-year overall survival rates of the entire cohort were 53.5%,20.4% and13.6% respectively.Cox's regression analysis showed that gender,ECOG score,number of distant metastases,and whether the primary lesions received radiotherapy were the independent prognostic factors (all P<0.05).The 1-,2-and 3-year survival rates in the radiochemotherapy group were 61%,29% and19%,and 40%,4%,0% in the chemotherapy group,respectively.In the radiochemotherapy group,the progression-free survival (PFS) and local progression-free survival (LPFS) were 8 months and 12.6 months,significantly longer compared with 4.7 months and 5.3 months in the chemotherapy group (both P<0.05).The OS of patients receiving dose>50Gy and ≤50Gy was 14.3 months and 8.2 months (P<0.05),8.6 months and 2.8 months for the PFS (P<0.05),and 15.2 months and 4.7 months for the LRFS (P<0.05),respectively.The number of distant metastases and the clinical efficacy for primary lesions were the independent prognostic factors in the radiochemotherapy group (both P<0.05).Conclusion Radiotherapy can improve the clinical prognosis of patients with stage Ⅳ esophageal cancer.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Étude pronostique langue: Chinois Texte intégral: Chinese Journal of Radiation Oncology Année: 2020 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Type d'étude: Étude pronostique langue: Chinois Texte intégral: Chinese Journal of Radiation Oncology Année: 2020 Type: Article