mTOR signaling pathway abnormality and epilepsy / 中华神经科杂志

ABSTRACT

Mammalian/mechanistic targets of rapamycin (mTOR) consist in two functional complexes, mTORC1 and mTORC2, which modulate the essential physical process in organism through responding to growth factor, glutamine, neurotransmitter and so on. Overaction of mTOR pathway in the central nervous system is responsible for epilepsy. The article reviews the existing reports to analyze and conclude the phenotypes of the mTOR related epilepsies as well as the likely mechanism, and to provide reference for the diagnosis and treatment of mTOR related epilepsy.