Research status of nicotine-aggravating the choroidal neovascularization formation in wet age-related macular degeneration / 中华眼底病杂志
Chinese Journal of Ocular Fundus Diseases
;
(6): 319-322, 2020.
Article
Dans Chinois
| WPRIM
| ID: wpr-871735
ABSTRACT
Choroidal neovascularization is the leading causes of central vision loss in wet age-related macular degeneration (wAMD) patients. Smoking not only aggravates the incidence and severity of the choroidal neovascularization of wAMD, but also affects the clinical treatment, making the prognosis worse. Nicotine, as an important harmful substance in tobacco, is an easily addictive and highly toxic alkaloid. Animal experiments and clinical studies have confirmed that nicotine can aggravate wAMD by mediating angiogenesis through nicotinic acetylcholine receptor, bone marrow blasts, inflammation, complement system, etc. Therefore, in order to early take appropriate intervention measures to prevent and delay the development, we should actively explore the exact pathogenesis by which nicotine aggravates the choroidal neovascularization.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of Ocular Fundus Diseases
Année:
2020
Type:
Article
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