Botulinum toxin type A injections in the facial plastic surgery incision: a meta-analysis / 中华医学美学美容杂志

ABSTRACT

Objective:To systematically evaluate the influence of botulinum toxin type A (BTXA) injections in the facial plastic surgery incision.Methods:A systematic literature search for studies which were published on PubMed, EMbase, Cochrane Central, CNKI and VIP, was performed from January 1998 to Octomber 2019. " Facial wound" , " Keloid" , " Scar" , " Cicatrix hypertrophy" , " Botulinum toxin" , " Boutulin" , " Botox" were set as the key words. We included trails related to the influence of botulinum toxin type A (BTXA) injections in the facial plastic surgery incision. The data were extracted and Rev Man 5.3 was used for meta-analysis.Results:Participants included seven randomized controlled trial of 450 patients. The Vancouver scar scale score of BTXA group was higher than those in the control group ( Z=23.92, P<0.01). The visual analogue scale score of BTXA group was higher than that of the control group ( Z=8.60, P<0.01). The scar width of BTXA group was less than that in the control group ( Z=10.84, P<0.01). Patients＇ satisfactory rate of BTXA group was higher than that of the control group ( Z=2.83, P<0.01). Conclusions:The injection treatment of BTXA for facial hyperplastic scar has certain curative effect, without obvious side effects, but the authenticity and stability of therapeutic effect have to be verified by more high quality research.