Risk factor analysis of deep venous thrombosis of the lower extremity in patients with breast cancer after surgery / 肿瘤研究与临床

ABSTRACT

Objective:To explore the risk factors of deep vein thrombosis (DVT) of the lower extremity in patients with breast cancer after surgery.Methods:A total of 95 female patients (the experimental group) with DVT of the lower extremity after breast cancer surgery in Shanxi Provincial Cancer Hospital from May 2016 to May 2019 were retrospectively analyzed, and 85 female breast cancer patients without DVT of the lower extremity after surgery from January 2019 to May 2019 were treated as the control group. The general information and plasma total cholesterol (TC), triglyceride (TG), D-dimer (D-D) levels were compared between the two groups, and the risk factors for DVT of the lower extremity in patients with breast cancer after surgery were explored.Results:The body weight [(69.05±6.49) kg vs. (61.75±6.62) kg], body mass index (BMI) [(29.89±1.78) kg/m 2 vs. (24.23±1.33) kg/m 2] and the age [(51.57±5.93) years old vs. (45.44±5.21) years old] in the experimental group were higher than those in the control group, and the differences were statistically significant (all P < 0.01). The TC level in the experimental group was slightly higher than that in the control group, and the difference was not statistically significant ( P > 0.05); the TG level in the experimental group was higher than that in the control group, and the difference was statistically significant ( P < 0.01); the D-D level of the experimental group at 10 d after operation was higher than that of the control group, and the difference was statistically significant ( P < 0.01). Logistic regression analysis showed that body weight > 66.25 kg ( OR = 1.507, 95% CI 1.101-2.122, P = 0.021), BMI > 25.43 kg/m 2 ( OR = 1.518, 95% CI 1.067-2.123, P = 0.017), TG≥1.8 mmol/L ( OR = 1.324, 95% CI 1.077-2.139, P = 0.045), postoperative D-D > 5.0 mg/L ( OR = 1.525, 95% CI1.110-2.231, P = 0.027), and surgery duration ≥ 2 h ( OR = 1.470, 95% CI 1.017-2.122, P = 0.033) were independent influencing factors of DVT in breast cancer patients. Conclusions:Breast cancer patients are prone to DVT of the lower extremity after operation. For patients with large body weight, high BMI, high blood lipids, high D-D and the operation duration ≥ 2 h, the postoperative prevention for DVT should be carried out early. Once there is a condition of lower extremity swelling, early treatment should be given.