A case of gonadoblastoma in patient with mixed gonadal dysgenesis / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1204-1208, 2002.
Article
Dans Coréen
| WPRIM
| ID: wpr-87506
ABSTRACT
Gonadoblastoma occurs almost always in association with a Y chromosome cell line, and developes in one third of patients with Mixed gonadal dysgenesis. Removing of gonads of intersex patients with the Y chromosome is very important because of the strong association of the genesis of tumor in dysgenetic gonads with the presence of a Y chromosome. But it is always possible that an XY cell line could be missed, or that a fragment from Y chromosome could have been translocated and not discovered by chromosomal analysis. PCR with Y specific probe or Southern blotting would reveal the presence of a Y or a translocated fragment. We experienced an 18-year-old woman represent with primary amenorrhea who had 45,X/46,X,+mar. Y-specific PCR revealed that the marker chromosome was drived from Y chromosome. After both gonadectomy and clitorial recession, we found the gonadoblastoma in dysgenetic testis. So we report it with brief review of literatures.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Testicule
/
Chromosome Y
/
Lignée cellulaire
/
Technique de Southern
/
Réaction de polymérisation en chaîne
/
Gonadoblastome
/
Aménorrhée
/
Dysgénésie gonadique mixte
/
Gonades
Limites du sujet:
Adolescent
/
Femelle
/
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
2002
Type:
Article
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