Clinical significance of minimal residual disease in B-lineage acute lymphoblastic leukemia pediatric patients with different fusion gene backgrounds / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1279-1285, 2020.
Article
Dans Chinois
| WPRIM
| ID: wpr-879790
ABSTRACT
OBJECTIVE@#To study the clinical significance of minimal residual disease (MRD) in B-lineage acute lymphoblastic leukemia (B-ALL) pediatric patients with different fusion gene backgrounds.@*METHODS@#A retrospective analysis was performed on the medical data of 441 B-ALL children who were treated from January 2008 to April 2015. Among the 441 children, 336 had negative fusion gene, 79 had positive @*RESULTS@#In patients with negative fusion gene, the positive MRD group had significantly lower overall survival (OS) rate and event-free survival (EFS) rate (@*CONCLUSIONS@#MRD has the most definite prognostic significance in pediatric B-ALL patients with negative fusion gene, while it has unsatisfactory prognostic significance in those with positive
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Leucémie-lymphome lymphoblastique à précurseurs B
/
Protéines de fusion oncogènes
/
Études rétrospectives
/
Maladie résiduelle
/
Protéines à homéodomaine
/
Survie sans rechute
/
Sous-unité alpha 2 du facteur CBF
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Enfant
/
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2020
Type:
Article
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