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Effect and mechanism of vascular endothelial growth factor-A on pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 103-110, 2021.
Article Dans Chinois | WPRIM | ID: wpr-879817
ABSTRACT
OBJECTIVE@#To study the role of vascular endothelial growth factor-A (VEGF-A) in pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension (HPH) by regulating survivin (SVV).@*METHODS@#A total of 96 neonatal rats were randomly divided into three groups HPH+VEGF-A group, HPH group, and control group. Each group was further randomly divided into 3-, 7-, 10-, and 14-day subgroups (@*RESULTS@#The HPH group had a significantly higher mean RVSP than the control and HPH+VEGF-A groups at each time point (@*CONCLUSIONS@#Prophylactic intratracheal administration of exogenous VEGF-A in neonatal rats with HPH can inhibit pulmonary vascular remodeling and reduce pulmonary arterial pressure by upregulating the expression of SVV in the early stage of hypoxia. This provides a basis for the interventional treatment of pulmonary vascular remodeling in neonatal HPH.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Artère pulmonaire / Rat Wistar / Facteur de croissance endothéliale vasculaire de type A / Remodelage vasculaire / Hypertension pulmonaire / Animaux nouveau-nés / Hypoxie Limites du sujet: Animaux langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2021 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Artère pulmonaire / Rat Wistar / Facteur de croissance endothéliale vasculaire de type A / Remodelage vasculaire / Hypertension pulmonaire / Animaux nouveau-nés / Hypoxie Limites du sujet: Animaux langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2021 Type: Article