Effect and mechanism of vascular endothelial growth factor-A on pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 103-110, 2021.
Article
Dans Chinois
| WPRIM
| ID: wpr-879817
ABSTRACT
OBJECTIVE@#To study the role of vascular endothelial growth factor-A (VEGF-A) in pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension (HPH) by regulating survivin (SVV).@*METHODS@#A total of 96 neonatal rats were randomly divided into three groups HPH+VEGF-A group, HPH group, and control group. Each group was further randomly divided into 3-, 7-, 10-, and 14-day subgroups (@*RESULTS@#The HPH group had a significantly higher mean RVSP than the control and HPH+VEGF-A groups at each time point (@*CONCLUSIONS@#Prophylactic intratracheal administration of exogenous VEGF-A in neonatal rats with HPH can inhibit pulmonary vascular remodeling and reduce pulmonary arterial pressure by upregulating the expression of SVV in the early stage of hypoxia. This provides a basis for the interventional treatment of pulmonary vascular remodeling in neonatal HPH.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Artère pulmonaire
/
Rat Wistar
/
Facteur de croissance endothéliale vasculaire de type A
/
Remodelage vasculaire
/
Hypertension pulmonaire
/
Animaux nouveau-nés
/
Hypoxie
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2021
Type:
Article
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