Analysis of the Different Therapeutic Effects in 21 Ph / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 38-42, 2021.
Article
Dans Chinois
| WPRIM
| ID: wpr-880028
ABSTRACT
OBJECTIVE@#To analyze the outcomes of the children suffered from philadelphia chromosome positive acute lymphoblastic leukemia (Ph@*METHODS@#21 cases of firstly diagnosed Ph@*RESULTS@#Among 21 patients, 17 were male and 4 were female with a median age of 8 years old (range, 4-12 years), the median follow-up time was 30 moths (range, 10-133 months). All the patients were treated with chemotherapy induced by the high-risk project of CCLG-ALL 2008. Among 14 patients treated with TKI plus chemotherapy, nine patients achieved complete remission. During 3 months after treatment, patients without complete molecular response or with the second complete remission and intensity desire of transplantation were treated with allo-HSCT, among 9 patients with allo-HSCT, six patients achieved long term survival.@*CONCLUSION@#At TKI era, TKI combined with strong chemotherapy can make Ph
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Chromosome Philadelphie
/
Études rétrospectives
/
Transplantation de cellules souches hématopoïétiques
/
Inhibiteurs de protéines kinases
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
Type d'étude:
Étude observationnelle
Limites du sujet:
Adulte très âgé
/
Enfant
/
Femelle
/
Humains
/
Bébé
/
Mâle
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2021
Type:
Article
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