Arctiin antagonizes triptolide-induced renal toxicity in rats via anti-inflammatory pathway / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1399-1405, 2020.
Article
Dans Chinois
| WPRIM
| ID: wpr-880776
ABSTRACT
OBJECTIVE@#To investigate the protective effect of arctiin with anti-inflammatory bioactivity against triptolide-induced nephrotoxicity in rats and explore the underlying mechanism.@*METHODS@#Forty SD rats were divided into 4 groups for gastric lavage of normal saline, arctiin (500 mg/kg), triptolide (500 μg/kg), or both arctiin (500 mg/kg) and triptolide (500 μg/kg). Blood samples were collected for analysis of biochemical renal parameters, and the renal tissues were harvested for determining the kidney index and for pathological evaluation with HE staining. In the @*RESULTS@#In SD rats, arctiin significantly antagonized triptolide-induced elevation of BUN, Scr and kidney index (@*CONCLUSIONS@#Arctiin can protect the kidney from triptolide-induced damages in rats possibly through the anti-inflammatory pathway.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénanthrènes
/
Rat Sprague-Dawley
/
Diterpènes
/
Composés époxy
/
Furanes
/
Glucosides
/
Rein
/
Anti-inflammatoires
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2020
Type:
Article
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