Establishment of a mouse model bearing orthotopic temozolomide-resistant glioma / 南方医科大学学报
Journal of Southern Medical University
;
(12): 69-74, 2021.
Article
Dans Chinois
| WPRIM
| ID: wpr-880829
ABSTRACT
OBJECTIVE@#To establish a mouse model bearing orthotopic temozolomide (TMZ)-resistant glioma that mimics the development of drug resistance in gliomas @*METHODS@#Seventy-eight adult C57BL/6 mice were randomly divided into 6 groups (@*RESULTS@#The mouse models bearing TMZresistant glioma was successfully established. The cells from the high-dose induced group showed a significantly higher colony-forming rate than those from the high-dose control group (@*CONCLUSIONS@#Progressive increase of TMZ doses in mice bearing orthotopic gliomas can effectively induce TMZ resistance of the gliomas.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs du cerveau
/
Résistance aux médicaments antinéoplasiques
/
Antinéoplasiques alcoylants
/
Lignée cellulaire tumorale
/
Modèles animaux de maladie humaine
/
Témozolomide
/
Gliome
/
Souris de lignée C57BL
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Journal of Southern Medical University
Année:
2021
Type:
Article
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