Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner
Protein & Cell
;
(12): 825-845, 2020.
Article
Dans Anglais
| WPRIM
| ID: wpr-880875
ABSTRACT
This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer samples, and elevated ERK5 expression in lung cancer was linked to the acquisition of increased metastatic and invasive potential. Importantly, we observed a significant correlation between ERK5 activity and FAK expression and its phosphorylation at the Ser
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Mouvement cellulaire
/
Système de signalisation des MAP kinases
/
Mitogen-Activated Protein Kinase 7
/
Focal adhesion kinase 1
/
Transition épithélio-mésenchymateuse
/
Cellules A549
/
Tumeurs du poumon
/
Invasion tumorale
/
Métastase tumorale
/
Protéines tumorales
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Protein & Cell
Année:
2020
Type:
Article
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