A Case of Bullous Pemphigoid Treated with Plasmapheresis and Pulse Cyclophosphamide
Annals of Dermatology
;
: 146-150, 1993.
Article
Dans Anglais
| WPRIM
| ID: wpr-88346
ABSTRACT
A 54-year-old woman with severe bullous pemphigoid (BP) associated with insulin dependent diabetes mellitus (DM), who showed unresponsiveness to conventional therapy with corticosteroids in combination of either cyclosporme or dapsone, was successfully treated with plasmapheresis followed each time by 3 successive days of pulse therapy of cyclophosphamide (500mg, intravenously). After six times of plasmapheresis, anti-basement membrane zone (BMZ) antibody titer decreased from 11280 to 140 and no new lesions developed at all. In severe refractory BP patients with uncontrolled DM, plasmapheresis is one of the valuable treatment modalities for a short period and the need for corticosteroids thus avoiding corticosteroid induced side effects. Herein we report a case of BP with uncontrolled DM who showed an excellent response to a low dose of corticosteroid and 150 mg oral azathioprine following plasmapheresis and cyclophosphamide pulse therapy.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Azathioprine
/
Pemphigoïde bulleuse
/
Plasmaphérèse
/
Hormones corticosurrénaliennes
/
Cyclophosphamide
/
Dapsone
/
Diabète
/
Insuline
/
Membranes
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Annals of Dermatology
Année:
1993
Type:
Article
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