Status and prospects of rotavirus particle-like vaccines / 中华微生物学和免疫学杂志

ABSTRACT

Human rotavirus (RV) is one of the main pathogens that cause non-bacterial acute gastroenteritis diseases globally. Live attenuated vaccine is an effective method to prevent RV infection. In order to improve the safety of RV vaccines, it is a good choice to develop other forms of vaccines other than live virus vaccines to avoid attenuated vaccine strains to restore virulence through back mutation or cause environmental contamination. This article reviews the research of RV virus like particle(VLP) vaccines.