Ligand fishing: a strategy for rapidly screening bioactive compounds from organism extracts / 药学学报
Acta Pharmaceutica Sinica
;
(12): 996-1005, 2021.
Article
Dans Chinois
| WPRIM
| ID: wpr-886974
ABSTRACT
Natural products are valuable resources for discovering new drugs. So far, screening bioactive compounds from organism extracts is still an important and challenging task. Traditional biometric guided method involves repeated fractionation steps and bioactivity tests, which are time-consuming, labor-consuming, and inefficient. Ligand fishing is a bioanalysis method for screening ligands from complex organism extracts based on intermolecular affinity interactions. It has the characteristics of strong specificity, high efficiency, and less requirement for sample pretreatment. In this review, we summarize the classification of ligand fishing strategy and its application in enzyme inhibitors screening. Finally, the development prospects of this technology are forecasted.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Etude diagnostique
/
Étude de dépistage
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2021
Type:
Article
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