Arachidonic acid metabolism in liver glucose and lipid homeostasis / 生理学报
Acta Physiologica Sinica
;
(6): 657-664, 2021.
Article
Dans Chinois
| WPRIM
| ID: wpr-887700
ABSTRACT
Arachidonic acid (AA) is an ω-6 polyunsaturated fatty acid, which mainly exists in the cell membrane in the form of phospholipid. Three major enzymatic pathways including the cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 monooxygenase (CYP450) pathways are involved in AA metabolism leading to the generation of a variety of lipid mediators such as prostaglandins, leukotrienes, hydroxyeicosatetraenoic acids (HETEs) and epoxyeicoastrienoic acids (EETs). These bioactive AA metabolites play an important role in the regulation of many physiological processes including the maintenance of liver glucose and lipid homeostasis. As the central metabolic organ, the liver is essential in metabolism of carbohydrates, lipids and proteins, and its dysfunction is associated with the pathogenesis of many metabolic diseases such as type 2 diabetes mellitus, dyslipidemia and nonalcoholic fatty liver disease (NAFLD). This article aims to provide an overview of the enzymatic pathways of AA and discuss the role of AA-derived lipid mediators in the regulation of hepatic glucose and lipid metabolism and their associations with the pathogenesis of major metabolic disorders.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Acide arachidonique
/
Diabète de type 2
/
Métabolisme lipidique
/
Glucose
/
Homéostasie
/
Foie
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Physiologica Sinica
Année:
2021
Type:
Article
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