Cross-talk between CXC chemokine ligand 10-CXC chemokine receptor 3 axis and CC chemokine ligand 17-CC chemokine receptor 4 axis in the pathogenesis of oral lichen planus / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 405-412, 2021.
Article
de En
| WPRIM
| ID: wpr-887751
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVES@#This study aimed to determine whether a correlation existed between CXC chemokine ligand 10 (CXCL10)-CXC chemokine receptor 3 (CXCR3) and CC chemokine ligand 17 (CCL17)-CC chemokine receptor 4 (CCR4) in the pathogenesis of oral lichen planus (OLP).@*METHODS@#Peripheral blood of OLP patients (non-erosive and erosive groups) and healthy controls were collected, and T cells were isolated and purified. T cells were co-cultured with three groups: blank, anti-CXCR3, and anti-CCR4. CXCR3 and CCR4 expression were detected by flow cytometry, and CXCL10 and CCL17 were detected by enzyme-linked immunosorbent assay, respectively.@*RESULTS@#The purities of T cells were all >95% in the three groups (@*CONCLUSIONS@#Two axes interact with each other in the pathogenesis of OLP and may play different roles in its occurrence and development.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Lichen plan buccal
/
Chimiokine CCL17
/
Chimiokine CXCL10
/
Récepteurs CCR4
/
Récepteurs CXCR3
/
Ligands
Type d'étude:
Etiology_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
West China Journal of Stomatology
Année:
2021
Type:
Article