Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875 / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 700-705, 2021.
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| ID: wpr-888801
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WPRO
ABSTRACT
Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875 yielded two pairs of new neolignans, (+) (7S, 8S, 7'S, 8'R) iso-magnosalicin (1a)/(-) (7R, 8R, 7'R, 8'S) iso-magnosalicin (1b) and (+) (7R, 8R, 7'S, 8'R) magnosalicin (2a)/(-) (7S, 8S, 7'R, 8'S) magnosalicin (2b), and four known metabolites, (±) acoraminol A (3), (±) acoraminol B (4), asaraldehyde (5), and 2, 4, 5-trimethoxybenzoic acid (6). Their structures, including absolute configurations, were determined by extensive analysis of NMR spectra, X-ray crystallography, and quantum chemical ECD calculations. The cytotoxic activity and Aβ
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WPRIM
langue:
En
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2021
Type:
Article