Bee venom phospholipase A2 ameliorates motor dysfunction and modulates microglia activation in Parkinson's disease alpha-synuclein transgenic mice
Experimental & Molecular Medicine
; : e244-2016.
Article
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| ID: wpr-89020
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ABSTRACT
α-Synuclein (α-Syn) has a critical role in microglia-mediated neuroinflammation, which leads to the development of Parkinson's disease (PD). Recent studies have shown that bee venom (BV) has beneficial effects on PD symptoms in human patients or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxin-induced PD mice. This study investigated whether treatment with BV-derived phospholipase A2 (bvPLA2) would improve the motor dysfunction and pathological features of PD in human A53T α-Syn mutant transgenic (A53T Tg) mice. The motor dysfunction of A53T Tg mice was assessed using the pole test. The levels of α-Syn, microglia and the M1/M2 phenotype in the spinal cord were evaluated by immunofluorescence. bvPLA2 treatment significantly ameliorated motor dysfunction in A53T Tg mice. In addition, bvPLA2 significantly reduced the expression of α-Syn, the activation and numbers of microglia, and the ratio of M1/M2 in A53T Tg mice. These results suggest that bvPLA2 could be a promising treatment option for PD.
Texte intégral:
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Indice:
WPRIM
Sujet Principal:
Maladie de Parkinson
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Phénotype
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Phospholipases
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Moelle spinale
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Venins d'abeille
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Abeilles
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Souris transgéniques
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1-Méthyl-4-phényl-1,2,3,6-tétrahydropyridine
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Technique d'immunofluorescence
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Microglie
Limites du sujet:
Animals
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Humans
langue:
En
Texte intégral:
Experimental & Molecular Medicine
Année:
2016
Type:
Article