Cryptotanshinone but not tanshinone IIA inhibits angiogenesisin vitro
Experimental & Molecular Medicine
;
: 133-137, 2005.
Article
Dans Anglais
| WPRIM
| ID: wpr-90138
ABSTRACT
In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity. Tanshinone IIA, another tanshinone isolated from S. miltiorrhiza, which is structurally very similar to cryptotanshinone except C-15 position of dihydrofuran ring does not inhibit angiogenesis induced by bFGF. These results demonstrate that cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Phénanthrènes
/
Médicaments issus de plantes chinoises
/
Mouvement cellulaire
/
Cellules cultivées
/
Facteur de croissance fibroblastique de type 2
/
Racines de plante
/
Néovascularisation physiologique
/
Inhibiteurs de l'angiogenèse
/
Salvia miltiorrhiza
/
Cellules endothéliales
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2005
Type:
Article
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