Correlates of Metabolic Abnormalities in Bipolar I Disorder at Initiation of Acute Phase Treatment
Psychiatry Investigation
;
: 78-84, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-90642
ABSTRACT
OBJECTIVE:
Treatment of bipolar patients is often complicated by metabolic abnormalities such as obesity, diabetes, and dyslipidemia. We therefore evaluated the prevalence of these abnormalities and their correlates, in bipolar I patients, at the time of commencement of pharmacological treatment for acute mood episodes.METHODS:
The study cohort consisted of 184 bipolar I patients hospitalized for treatment of acute mood episodes. Socio-demographic and clinical variables were noted and metabolic parameters, including body mass index, fasting plasma glucose, fasting total cholesterol, and current treatment(s) for diabetes and/or dyslipidemia were measured before initiating medication(s).RESULTS:
Fifty-six (30.4%) subjects met our criteria for obesity; 80 (43.5%) had hyperglycemia, with 8 (4.3%) receiving anti-diabetic medication; and 38 (20.7%) had hypercholesterolemia, with 2 (1.1%) receiving cholesterol-lowering agents. We found that male sex (chi-square=5.359, p=0.021), depressed or mixed state versus manic state (chi-square=4.302, p=0.038), and duration of illness (t=2.756, p=0.006) were significantly associated with obesity. Older age (t=3.668, p<0.001), later age of disease onset (t=2.271, p=0.024), and lower level of educational attainment (beta=-0.531, p=0.001) were associated with hyperglycemia.CONCLUSION:
Our finding that metabolic abnormalities are prevalent when initiating acute pharmacological treatment in bipolar I patients indicates that these factors should be integrated into treatment plans at the onset of disease management.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasma sanguin
/
Trouble bipolaire
/
Indice de masse corporelle
/
Cholestérol
/
Prévalence
/
Études de cohortes
/
Jeûne
/
Prise en charge de la maladie
/
Dyslipidémies
/
Glucose
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Psychiatry Investigation
Année:
2009
Type:
Article
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