Risk factors of post-bronchiolitis wheezing in infants / 国际儿科学杂志

ABSTRACT

Objective:To explore the risk factors of recurrent wheezing in infants after bronchiolitis, and to study the influence of different risk factors on recurrent wheezing, so as to provide strategies for clinical treatment and prevention.Methods:Four hundred and ninety-two patients with bronchiolitis in Department of Respiratory Pediatrics, Shengjing Hospital of China Medical University from January 2016 to December 2018 were selected and divided into wheezing group(147 cases)and non wheezing group(345 cases)according to the recurrence of wheezing after bronchiolitis.The data of the selected cases were collected, the risk factors were analyzed and the incidence of recurrent wheezing in patients with different risk factors for bronchiolitis was calculated.Results:In this study, 492 children with bronchiolitis were included, 147 cases(29.9%)had recurrent wheezing.There were significant differences in breastfeeding, artificial feeding, history of eczema, positive allergens reported by parents, family history of asthma, parents suffering from allergic disease, smoke exposure and severe illness between wheezing group and non wheezing group( P<0.05). Logistic regression analysis showed that the risk factors of wheezing after bronchiolitis were severe illness, positive allergens reported by parents, parents suffering from allergic disease, smoke exposure( P<0.05). Patients with one of these risk factors for bronchiolitis had a 16.7%~48.3% chance of recurrent wheezing.Patients with two of these risk factors for bronchiolitis had a 33.3%~100% chance of recurrent wheezing.Patients with three of these risk factors for bronchiolitis had a 50%~100% chance of recurrent wheezing.Patients with bronchiolitis with all four risk factors had a recurrent wheezing rate of 100%. Conclusion:The recurrent wheezing rate of infants with bronchiolitis was at a high level.The risk factors of wheezing after bronchiolitis were severe illness, positive allergen reported by parents, parents suffering from allergic disease and smoke exposure.The more risk factors, the higher probability of wheezing after bronchiolitis.