Progress in epigenetics of congenital heart disease / 国际儿科学杂志

ABSTRACT

Congenital heart disease(CHD)is one of the most common congenital defects that caused by fetal cardiovascular dysplasia.The global incidence rate is about 9/1 000 and is still rising.Previous reports have shown that congenital heart disease(CHD)incidence can be influenced by genetic etiology and environmental risk factors.And the gene-environmental interaction can affect the development and differentiation of myocardium through epigenetic regulation by means of DNA methylation, histone and RNA modification, etc.In this paper, we review the epigenetics of congenital heart disease to discuss the current progress and point out future direction of the etiology of congenital heart disease.