Circadian rhythm disorder of blood pressure in Parkinson′s disease / 中华神经科杂志

ABSTRACT

Circadian rhythm disorder of blood pressure is a common abnormal form of blood pressure in Parkinson′s disease, including abnormal circadian blood pressure pattern, nocturnal hypertension, increased blood pressure variability and awakening hypotension. The pathogenesis of circadian rhythm disorder of blood pressure in Parkinson′s disease is complex, which involves the disruption of circadian rhythm, cardiovascular dysfunction, abnormal hormone secretion and the disorders of sleep-wake cycle and structure. At the same time, it is affected by many factors such as circadian activity rhythm, emotion, anti-Parkinson′s disease drugs and so on. Studies have shown that the circadian rhythm disturbance of blood pressure is closely related to the clinical phenotypes, progression and prognosis of Parkinson′s disease. Therefore, it is suggested to enhance the screening and intervention of circadian rhythm disorders of blood pressure to optimize treatment and improve quality of life in Parkinson′s disease.