Progress in the mechanism of deubiquitinating enzymes of ovarian tumor-associated protease (OTUs) family in viral infection / 中华微生物学和免疫学杂志

ABSTRACT

Ubiquitin is a widespread form of post-translational modification of proteins in cells, which plays an important role in regulating immune response, inflammatory response, cell connection, cell cycle, apoptosis, DNA damage repair and many other life processes. The ubiquitin modification of proteins is also reversible. Deubiquitinating enzymes regulate the life span or function of proteins through hydrolyzing polyubiquitin chains to deubiquitinate substrate proteins, thus playing a role in ubiquitin-mediated signal transduction pathways. Ovarian tumor-associated proteases (OTUs) belong to the cysteine family. It has been found that many members of the OTUs family are closely related to the regulation of viral infection. This paper reviewed the role and mechanism of OTUs in host antivirus response in recent years.