Progress of tumor-associated neutrophils in colorectal cancer / 肿瘤研究与临床

ABSTRACT

Colorectal cancer is one of the most common causes of cancer death worldwide. In recent years, the number of patients with colorectal cancer has gradually increased. It has been proved that inflammation plays a special role in the occurrence and development of cancer. As important inflammatory cells, the role of neutrophils in tumors has gradually become research hotspots. It has been found that tumor-associated neutrophils can be polarized into pro-tumor and anti-tumor phenotypes in the tumor microenvironment, and have the ability to promote angiogenesis and tumor cell migration. This article reviews the role of tumor-associated neutrophils in the occurrence, development and metastasis of colorectal cancer, and the possibility of tumor-associated neutrophils as potential targets for cancer treatment.