Biocompatibility and Bone Conductivity of Porous Calcium Metaphosphate Blocks / 대한치주과학회지
The Journal of the Korean Academy of Periodontology
;
: 559-567, 1998.
Article
Dans Coréen
| WPRIM
| ID: wpr-92053
ABSTRACT
While calcium phosphate ceramics meet some of the needs for bone replacement, they have some limitation of unresorbability and fibrous encapsulation without direct bone apposition during bone remodelling. To address these problem, we developed a new ceramic, calcium metaphosphate(CMP), and report herein the biologic response to CMP in subcutaneous tissue, muscle and bone. Porous CMP blocks were prepared by condensation of anhydrous Ca(H2PO4)2 to form non-crystalline Ca(PO3)2. Macroporous scaffolds were made using a polyurethane sponge method. CMP block possesses a macroporous structure with approximate pore size range of 0.3-1mm. CMP blocks were implanted in 8 mm sized calvarial defect, subcutaneous tissue and muscle of 6 Newzealand White rabbits and histologic observation were performed at 4 and 6 weeks later. CMP blocks in subcutaneous tissue and muscle were well adapted without any adverse tissue reaction and resorbed slowly and spontaneously. Histologic observation of calvarial defect at 4 and 6 weeks revealed that CMP matrix were mingled with and directly apposed to new bone without any intervention of fibrous connective tissue. CMP blocks didn't show any adverse tissue reaction and resorbed spontaneously also in calvarial defect. This result revealed that CMP had a high affinity for bone and was very biocompatible. From this preliminary result, it was suggested that CMP was a promising ceramic as a bone substitute and tissue engineering scaffold for bone formation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
The Journal of the Korean Academy of Periodontology
Année:
1998
Type:
Article
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