Antimicrobial Effects of Oleanolic Acid against Streptococcus mutans and Streptococcus sobrinus Isolated from a Korean Population
International Journal of Oral Biology
;
: 191-195, 2010.
Article
Dans Coréen
| WPRIM
| ID: wpr-92232
ABSTRACT
Oleanolic acid is a natural triterpenoid that exists widely in foods and some medicinal herbs. The purpose of this study was to determine the antimicrobial activity of oleanolic acid against Streptococcus mutans strains isolated from a Korean population. Antimicrobial activity against these bacteria was evaluated by minimal inhibitory concentration (MIC) and time kill curves. The tolerance of human gingival fibroblasts and human periodontal ligaments to oleanolic acid was tested using a methyl thiazolyl tetrazolium (MTT) assay. The MIC90 value of oleanolic acid for both S. mutans and S. sobrinus isolated from Koreans was 8 microg/ml. Oleanolic acid showed bactericidal effects against S. mutans ATCC 25175T and S. sobrinus ATCC 33478T at 1 x MIC (8 microg/ml) and had no cytotoxic effects against KB cells at this dose. The results suggest that oleanolic acid could be useful in the future development of oral hygiene products for the prevention of dental caries.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Acide oléanolique
/
Hygiène buccodentaire
/
Desmodonte
/
Plantes médicinales
/
Streptococcus
/
Streptococcus mutans
/
Bactéries
/
Cellules KB
/
Streptococcus sobrinus
/
Caries dentaires
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
International Journal of Oral Biology
Année:
2010
Type:
Article
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