Protective Effect of HP08-0111 on Ligature-Induced Periodontitis
International Journal of Oral Biology
; : 145-151, 2010.
Article
de En
| WPRIM
| ID: wpr-92238
Bibliothèque responsable:
WPRO
ABSTRACT
Periodontitis is an inflammatory disorder of the periodontium and is characterized by destruction of the tooth supporting tissues, mediated by the upregulation of synthesis and release of a variety of pro-inflammatory factors. Inflammatory cytokines and prostaglandins upregulate RANKL and its subsequent binding to RANK stimulates osteoclast formation, resorption activity, and survival. In our present study, we investigated the effects of HP08-0111, composed of Coptis japonica (Thunb.) Makino, vitamin C and vitamin E, upon inflammatory responses, osteoclastogenesis and alveolar bone loss. HP08-0111 decreased the expression of IL-1beta and COX2 on LPS-induced RAW 264.7 cells and inhibited osteoclast-specific genes such as c-Fos, MMP-9, and TRAP. HP08-0111 also exhibited protective effects against alveolar bone loss in rats with ligature-induced periodontitis. Our results suggest that HP08-0111 is potentially an important therapeutic tool for the treatment of disorders associated with bone loss such as periodontitis.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Ostéoclastes
/
Parodontite
/
Acide ascorbique
/
Dent
/
Vitamine E
/
Vitamines
/
Parodonte
/
Régulation positive
/
Prostaglandines
/
Résorption alvéolaire
Limites du sujet:
Animals
langue:
En
Texte intégral:
International Journal of Oral Biology
Année:
2010
Type:
Article