Value of serum miR-922 and miR-506 expression levels in the diagnosis and prognostic assessment of childhood acute lymphoblastic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1021-1026, 2021.
Article
Dans Anglais
| WPRIM
| ID: wpr-922385
ABSTRACT
OBJECTIVES@#To study the value of serum miR-922 and miR-506 expression levels in the diagnosis and prognostic assessment of childhood acute lymphoblastic leukemia (ALL).@*METHODS@#A total of 132 children with ALL (ALL group) and 80 healthy children (healthy control group) were prospectively selected in this study. Quantitative real-time polymerase chain reaction was used to measure the expression levels of serum miR-922 and miR-506 in both groups. Receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic value of miR-922 and miR-506 for childhood ALL. The Kaplan-Meier method was used to plot survival curves, and multivariate COX regression models were used to analyze the risk factors for poor prognosis in children with ALL.@*RESULTS@#The ALL group had significantly higher expression levels of serum miR-922 and miR-506 than the control group (@*CONCLUSIONS@#The expression levels of miR-922 and miR-506 are of good value in the diagnosis and prognostic assessment of childhood ALL.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Marqueurs biologiques tumoraux
/
Courbe ROC
/
MicroARN
/
Estimation de Kaplan-Meier
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
Type d'étude:
Etude diagnostique
/
Étude pronostique
Limites du sujet:
Enfant
/
Humains
langue:
Anglais
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2021
Type:
Article
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