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Ginsenoside Rg1 ameliorates blood-brain barrier disruption and traumatic brain injury
Acta Pharmaceutica Sinica B ; (6): 3493-3507, 2021.
Article de En | WPRIM | ID: wpr-922810
Bibliothèque responsable: WPRO
ABSTRACT
During the traumatic brain injury (TBI), improved expression of circulatory miR-21 serves as a diagnostic feature. Low levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and blood-brain barrier (BBB) permeability, reduce nerve apoptosis, restore neural function and ameliorate TBI. We evaluated the role of macrophage derived exosomes-miR-21 (M-Exos-miR-21) in disrupting BBB, deteriorating TBI, and Rg1 interventions. IL-1
Mots clés
Texte intégral: 1 Indice: WPRIM langue: En Texte intégral: Acta Pharmaceutica Sinica B Année: 2021 Type: Article
Texte intégral: 1 Indice: WPRIM langue: En Texte intégral: Acta Pharmaceutica Sinica B Année: 2021 Type: Article