Association between Maternal Drug Use and Cytochrome P450 Genetic Polymorphisms and the Risk of Congenital Heart Defects in Offspring / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 45-57, 2022.
Article
Dans Anglais
| WPRIM
| ID: wpr-927631
ABSTRACT
OBJECTIVE@#This study aimed to assess the associations between maternal drug use, cytochrome P450 ( CYP450) genetic polymorphisms, and their interactions with the risk of congenital heart defects (CHDs) in offspring.@*METHODS@#A case-control study involving 569 mothers of CHD cases and 652 controls was conducted from November 2017 to January 2020.@*RESULTS@#After adjusting for potential confounding factors, the results show that mothers who used ovulatory drugs (adjusted odds ratio [a OR] = 2.12; 95% confidence interval [ CI] 1.08-4.16), antidepressants (a OR = 2.56; 95% CI 1.36-4.82), antiabortifacients (a OR = 1.55; 95% CI 1.00-2.40), or traditional Chinese drugs (a OR = 1.97; 95% CI 1.26-3.09) during pregnancy were at a significantly higher risk of CHDs in offspring. Maternal CYP450 genetic polymorphisms at rs1065852 (A/T vs. A/A OR = 1.53, 95% CI 1.10-2.14; T/T vs. A/A OR = 1.57, 95% CI 1.07-2.31) and rs16947 (G/G vs. C/C OR = 3.41, 95% CI 1.82-6.39) were also significantly associated with the risk of CHDs in offspring. Additionally, significant interactions were observed between the CYP450genetic variants and drug use on the development of CHDs.@*CONCLUSIONS@#In those of Chinese descent, ovulatory drugs, antidepressants, antiabortifacients, and traditional Chinese medicines may be associated with the risk of CHDs in offspring. Maternal CYP450 genes may regulate the effects of maternal drug exposure on fetal heart development.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Complications de la grossesse
/
Cytochrome P-450 enzyme system
/
Génotype
/
Cardiopathies congénitales
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Nouveau-né
/
Grossesse
langue:
Anglais
Texte intégral:
Biomedical and Environmental Sciences
Année:
2022
Type:
Article
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