Clinical Efficacy of Combination Chemotherapy with Ifosfamide Cisplatin, and Etoposide(ICE) in Advanced Non-Small Cell Lung Cancer / 결핵
Tuberculosis and Respiratory Diseases
;
: 309-316, 2002.
Article
Dans Coréen
| WPRIM
| ID: wpr-92829
ABSTRACT
BACKGROUND:
To evaluate the efficacy and toxicity of combination chemotherapy using ifosfamide, cisplatin, and etoposide in patients with advanced non-small cell lung cancer(NSCLC). MATERIALS ANDMETHODS:
Thirty-three patients with inoperable NSCLC(stage III b+IV) who had measurable diseases, and had not been treated with chemotherapeutic drugs, were enrolled in this study(from March 1995 to December 1996). The patients received ifosfamide(1500mg/m2/day, a full drop with Mesna on days 1-5), Cisplatin (80mg/m2/day infusion with a hydration on day 2), and Etoposide (100mg/m2/day infusion for 2 hours on days 1-3). The treatment was repeated every 4 weeks.RESULTS:
Ten patients showed a partial responses (30.3%). The overall survival time of the responders was longer than that of the non-responders (median 55 vs 22 weeks, p=0.01). The toxicities of this treatment were tolerable. Grade 3 or 4 leukopenia was observed in 21%. There was 1 death related to febrile neutropenia. The non-hematologic toxicity was mild. The relative dose intensity given to the patients was 0.86 ifosfamide, 0.87 cisplatin, and 0.89 etoposide, showing an average dose intensity of 0.87.CONCLUSIONS:
A combination regimen of ifosfamide, cisplatin, and etoposide is effective and tolerable for treating advanced non-small cell lung cancer.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Cisplatine
/
Mesna
/
Carcinome pulmonaire non à petites cellules
/
Traitement médicamenteux
/
Association de médicaments
/
Étoposide
/
Neutropénie fébrile
/
Ifosfamide
/
Leucopénie
/
Poumon
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Tuberculosis and Respiratory Diseases
Année:
2002
Type:
Article
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