Your browser doesn't support javascript.
loading
Efficacy and safety of bosentan in the treatment of persistent pulmonary hypertension of the newborn: a Metaanalysis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 319-325, 2022.
Article Dans Anglais | WPRIM | ID: wpr-928607
ABSTRACT
OBJECTIVES@#To systematically evaluate the efficacy and safety of bosentan in the treatment of persistent pulmonary hypertension of the newborn (PPHN).@*METHODS@#Chinese Journal Full-text Database, Weipu Database, Wanfang Data, China Biology Medicine disc, PubMed, Web of Science, Embase, and Cochrane Library were searched for literature on bosentan in the treatment of PPHN published up to August 31, 2021.@*RESULTS@#A total of 8 randomized controlled trials were included for Meta analysis. The results of the Meta analysis showed that compared with the control group, the bosentan treatment group had a significantly lower treatment failure rate (RR=0.23, P<0.001), a significantly greater reduction in pulmonary artery pressure [mean difference (MD)=-11.79, P<0.001)], significantly greater increases in oxygen partial pressure (MD=10.21, P=0.006) and blood oxygen saturation (MD=8.30, P<0.001), and a significantly shorter length of hospital stay (MD=-1.35, P<0.001). The descriptive analysis showed that the bosentan treatment group had a lower degree of tricuspid regurgitation than the control group after treatment. The main adverse reactions of bosentan treatment included abnormal liver function, anemia and edema. The results of subgroup analysis based on treatment regimen, research area, and drug dose were consistent with those before stratification.@*CONCLUSIONS@#Bosentan is effective in the treatment of PPHN. However, when using bosentan, attention should be paid to adverse reactions such as abnormal liver function.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Chine / Échec thérapeutique / Bosentan / Hypertension pulmonaire Type d'étude: Essai clinique contrôlé / Revues systématiques évaluées Limites du sujet: Humains / Nouveau-né Pays comme sujet: Asie langue: Anglais Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2022 Type: Article

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Chine / Échec thérapeutique / Bosentan / Hypertension pulmonaire Type d'étude: Essai clinique contrôlé / Revues systématiques évaluées Limites du sujet: Humains / Nouveau-né Pays comme sujet: Asie langue: Anglais Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2022 Type: Article