Research Progress of Intercellular Mitochondrial Transfer in the Development of Hematological Malignant Tumors --Review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 310-313, 2022.
Article
Dans Chinois
| WPRIM
| ID: wpr-928711
ABSTRACT
In recent years, studies have found that mitochondrial transfer between leukemic cells and different types of cells in their bone marrow microenvironment, especially mesenchymal stem cells, plays a key role in the occurrence, development and drug resistance of hematological malignant tumors. This paper mainly introduces the role and latest research progress of mitochondrial transfer in acute and chronic myeloid leukemia, acute lymphoblastic leukemia and multiple myeloma, and briefly describes the mechanism of drug resistance caused by mitochondrial transfer in leukemic cells during chemotherapy. The aim is to provide a new idea and theoretical basis for using intercellular mitochondrial transfer as a potential therapeutic target.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Moelle osseuse
/
Tumeurs hématologiques
/
Microenvironnement tumoral
/
Cellules souches mésenchymateuses
/
Mitochondries
/
Myélome multiple
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2022
Type:
Article
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