Sesquiterpenoids from the leaves of Sarcandra glabra / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 215-220, 2022.
Article
Dans Anglais
| WPRIM
| ID: wpr-929254
ABSTRACT
Sarglanoids A-F, six new sesquiterpenoids belonging to eudesmane (1-5) and eremophilane (6) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configurations were elucidated through extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Compounds 1-2 were rare N-containing eudesmane-type sesquiterpenoids. Compound 3 exhibited inhibitory activity against nitric oxide (NO) production in lipopolysaccharides (LPS)-induced RAW 264.7 cells with IC50 values at 20.00 ± 1.30 μmol·L-1. These findings provide scientific evidence for sesquiterpenoids as the material foundation of S. glabra.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Graines
/
Sesquiterpènes
/
Structure moléculaire
/
Feuilles de plante
/
Sesquiterpènes polycycliques
langue:
Anglais
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2022
Type:
Article
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