Progress of tryptophan and its metabolites in pathogenesis of allergic asthma / 国际儿科学杂志

ABSTRACT

Airway epithelial damage, increased Th2 inflammatory response, and impaired immune regulatory T cell function are important mechanisms for the development of asthma.Indoleamine 2, 3-dioxygenase(IDO) is induced by LPS and IFN-γ, which regulates the differentiation of naive T cells into CD4 + CD25 + regulatory T cells(Treg)and induces immune tolerance.It can inhibit eosinophilic airway inflammation.Decreased IDO activity may promote the development of asthma.Tryptophan metabolites act on AhR receptors to promote the production of IL-22 and enhance the integrity of the epithelium and its resistance to infection.The Th17/Treg balance induced by specific immunotherapy could be altered, and Treg cell proliferation was observed.Tryptophan metabolites can reduce airway inflammation and inflammatory cytokine infiltration.D-tryptophan can promote the diversity of intestinal flora, increase the number of Treg in lung and colon, reduce Th2 reaction, and reduce airway hyperresponsiveness.Tryptophan and its metabolites, IDO and D-tryptophan play an important role in the occurrence, development and specific immunotherapy of asthma.